Oxalis corniculata (family: Oxalidaceae) is widely used as a medicinal plant. We evaluated the analgesic activity of ethanolic extract of whole plant of Oxalis corniculata. The analgesic activity of the extract was evaluated by using Acetic acid-induced writhing method, Eddy’s hot plate method and Tail immersion test. The percentage inhibition of writhers or percentage protection were found to be 44% and 47% for extract at a dose 100 and 300 mg/kg body weight, respectively, in the acetic acid-induced writhing method (P<0.01) when compared with control. The percentage increase in reaction time at 60 minutes were 166% and 200% for extract at a dose of 100 and 300 mg/kg body weight, respectively, in Eddy’s hot plate method (P<0.001) when compared with control. The percentage increase in reaction time at 60 minutes were 120% and 240% for extract at a dose of 100 and 300 mg/kg body weight, respectively in tail immersion test (P<0.01, P<0.001) when compared with control. Keywords: Oxalis corniculata, analgesic activity, acetic acid-induced writhing, eddy’s hot plate, tail immersion test
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